Antiplatelet and anti-proliferative action of disintegrin from Echis multisquamatis snake venom
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چکیده
منابع مشابه
Antiplatelet and anti-proliferative action of disintegrin from Echis multisquamatis snake venom
AIM To purify the platelet aggregation inhibitor from Echis multisquamatis snake venom (PAIEM) and characterize its effect on platelet aggregation and HeLa cell proliferation. METHODS Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and matrix assisted laser desorption/ionization time-of-flight (MALDI-TOF) were used for PAIEM identification. Platelet aggregation in the pre...
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A serine proteinase with a fibrinogenase activity was isolated from the venom of viper Echis multisquamatis. Isolation was performed by the combination of Q-sepharose and Heparine-agarose chromatography. The enzyme has apparent molecular weight 35 ± 1 kDа. It posesses strong fibrinogen β-chain, moderate αchain proteolytic activity, arginine-amidase activity as the majority of serine fibrinogena...
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متن کاملContortrostatin, a snake venom disintegrin with anti-angiogenic and anti-tumor activity.
Disintegrins are soluble peptides found in snake venom. They bind to Arg-Gly-Asp (RGD)-responsive integrins with high affinity (nM range) and block integrin function. Contortrostatin (CN), the disintegrin from southern copperhead venom, is a homodimer with a molecular weight of 13,500. Each chain contains 65 amino acids with an Arg-Gly-Asp motif. CN has anti-invasive and anti-adhesive activity ...
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ژورنال
عنوان ژورنال: Croatian Medical Journal
سال: 2017
ISSN: 0353-9504,1332-8166
DOI: 10.3325/cmj.2017.58.118